MicroRNA-210: A unique and pleiotropic hypoxamir
نویسندگان
چکیده
منابع مشابه
Hypoxia-Inducible MiR-210 Is an Independent Prognostic Factor and Contributes to Metastasis in Colorectal Cancer
MicroRNA-210 (miR-210), the master hypoxamir, plays pleiotropic roles in certain cancers; however, its role in the development of human colorectal cancer remains unclear. Herein, we report that miR-210 is frequently up-regulated in colorectal cancer tissues, with high miR-210 expression significantly correlating with large tumor size, lymph node metastasis, advanced clinical stage and poor prog...
متن کاملFunction and mechanism of microRNA-210 in acute cerebral infarction
Acute cerebral infarction (ACI) is a common cerebrovascular disease. Previous studies have indicated that microRNAs (miRs) are aberrantly expressed in patients with ACI. However, the functions of miRs in the pathogenesis of ACI still require further investigation. The aim of the present study was to investigate the function of miR-210 in ACI and its associated mechanism. The expression of miR-2...
متن کاملNeuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy
OBJECTIVES To reveal the effect of microRNA-210 on cell apoptosis caused by HIE. METHODS Postnatal day 7 rats after HI injury were intraventricularly injected with microRNA-210 mimic, microRNA-210 inhibitor, or physiological saline. 72 h after the injection, rats were sacrificed and the left hemispheres were collected. The expression level of microRNA-210 was identified by quantitative real-t...
متن کاملAdministration of microRNA-210 promotes spinal cord regeneration in mice.
STUDY DESIGN Experimental animal study of treatment of spinal cord injury (SCI). OBJECTIVE To investigate the therapeutic effects of administering microRNA-210 (miR-210) to promote angiogenesis in a mouse SCI model. SUMMARY OF BACKGROUND DATA Despite many previous studies regarding SCI, there is no established treatment in clinical practice. miRNAs have attracted immense attention because o...
متن کاملMicroRNA‐210 Decreases heme Levels by Targeting Ferrochelatase in Cardiomyocytes
BACKGROUND MicroRNA-210 (miR-210) increases in hypoxia and regulates mitochondrial respiration through modulation of iron-sulfur cluster assembly proteins (ISCU1/2), a protein that is involved in Fe/S cluster synthesis. However, it is not known how miR-210 affects cellular iron levels or production of heme, another iron containing molecule that is also needed for cellular and mitochondrial func...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.6.11006